Whole exome sequencing reveals somatic mutations in HRAS and KRAS which cause nevus sebaceus
نویسندگان
چکیده
Jonathan L. Levinsohn1, Li C. Tian1, Lynn M. Boyden2, Jennifer M. McNiff1, Deepak Narayan3, Erin S. Loring2, Duri Yun4, Jeffrey L. Sugarman5, John D. Overton2,6, Shrikant M. Mane2,6, Richard P. Lifton2,6,7, Amy S. Paller4, Annette M. Wagner4, Richard J. Antaya1,8, and Keith A. Choate1 1Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 2Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 3Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 4Department of Dermatology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois
منابع مشابه
Identification of Somatic KRAS Mutation in a Korean Baby with Nevus Sebaceus Syndrome
Nevus sebaceus is a benign hamartoma of the epidermis, hair follicles, and sebaceous and apocrine glands. It typically appears as a yellow-orange to pink, finely papillomatous alopecic plaque that is often oval or linear. It usually presents at birth, preferentially affects the scalp and face, and is not uncommon, occurring in approximately 1 in 1,000 live births [1]. A recent study by Groesser...
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